DNA methyltransferase inhibitors and their emerging role in epigenetic therapy of cancer
A Gnyszka, Z JASTRZĘBSKI, S Flis - Anticancer research, 2013 - ar.iiarjournals.org
… DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most successful
epigenetic … DNA methylation is the most characterized epigenetic phenomenon described …
epigenetic … DNA methylation is the most characterized epigenetic phenomenon described …
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
F Lyko, R Brown - Journal of the National Cancer Institute, 2005 - academic.oup.com
… the role of DNA methyltransferase inhibitors in the further development of epigenetic cancer
therapies… patterns can also be used to develop and refine epigenetic therapies for cancer. In …
therapies… patterns can also be used to develop and refine epigenetic therapies for cancer. In …
DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer
V Singh, P Sharma, N Capalash - Current cancer drug targets, 2013 - ingentaconnect.com
… Abstract: DNA methylation is an epigenetic modification involved in gene expression
regulation. In cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …
regulation. In cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …
Epigenetic cancer therapies: DNA methyltransferase inhibitors
R Brown, G Strathdee - Expert Opinion on Investigational Drugs, 2002 - Taylor & Francis
… DNMT. Given our increased understanding of the relationships between DNA methylation
and other mechanisms of epigenetic … proteins and histone modifications, there is now a need …
and other mechanisms of epigenetic … proteins and histone modifications, there is now a need …
DNA methyltransferase inhibitors for cancer therapy
B Brueckner, D Kuck, F Lyko - The Cancer Journal, 2007 - journals.lww.com
… are not the only potentially druggable targets for epigenetic therapies; however, epigenetic
… their development into the currently most advanced epigenetic drugs for clinical use. …
… their development into the currently most advanced epigenetic drugs for clinical use. …
DNA methyltransferase inhibitors for cancer therapy
JL Medina-Franco, J Yoo… - Epigenetic technological …, 2015 - Elsevier
DNA methyltransferases (DNMTs) are promising epigenetic targets for the … DNMT inhibitors
(DNMTi) approved by the Food and Drug Administration of the United States for the treatment …
(DNMTi) approved by the Food and Drug Administration of the United States for the treatment …
Emerging DNA methylation inhibitors for cancer therapy: challenges and prospects
A Gonzalez-Fierro… - Expert Review of …, 2019 - Taylor & Francis
… the role of altered DNA methylation in cancer. Global hypomethylation in some models promotes
and in other models protects cancer … The complexity of DNA methylation makes hard to …
and in other models protects cancer … The complexity of DNA methylation makes hard to …
[HTML][HTML] DNA methyltransferases: a novel target for prevention and therapy
… lost DNA methylation to varying levels in 14 out of 15 cancer … This study highlights the
importance of DNA methylation … for cervical cancer and provides insight into the possible role of …
importance of DNA methylation … for cervical cancer and provides insight into the possible role of …
Epigenetic targets and their inhibitors in cancer therapy
L Zhao, YT Duan, P Lu, ZJ Zhang… - Current topics in …, 2018 - ingentaconnect.com
… the role of epigenetic modifications (DNA methylation, histone … new inhibitors (also called
epigenetic drugs), as well as their … inhibitors have the potential to be used in epigenetic therapy …
epigenetic drugs), as well as their … inhibitors have the potential to be used in epigenetic therapy …
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application
C Hu, X Liu, Y Zeng, J Liu, F Wu - Clinical Epigenetics, 2021 - Springer
… between DNMT inhibitors and chemotherapeutic drugs make combining epigenetic therapy
and … Moreover, DNMT inhibitors can reverse epidermal growth factor (EGF) receptor (EGFR) …
and … Moreover, DNMT inhibitors can reverse epidermal growth factor (EGF) receptor (EGFR) …